Alex and Charlie are back on track and planning their wedding when disaster strikes at a chapel and Alex and Charlie have to put their wedding on hold to save the life of a bride. Zach tries extraordinary means to save a down-on-his-luck patient with liver disease who is ineligible for a transplant. Ultimately, it’s Jackson who steps up to the plate and offers to be his live donor. Shahir and Dana’s coma patient wakes up without any memory of the last 20 years of his life – including his wife. They must get this patient to remember who he is while at the same time grappling with their own issues.